Rumble in the Tunnel: Find the Enemigos' hideout and finish the rumble.Send Out the Clowns: Kill all the Hobo Clowns in the level.No Privacy: Open all the curtains on the train.Look Out Below: Kill four Enemigos by dropping trunks on them.Train Conductor: Find six train tickets in the luggage.Alpaca Blast: Juggle and launch Alpaca Jack into the stratosphere.Shootout: Defeat Alpaca Jack with his own Revolver.Lumberjack: Cut six logs with a Chainsaw.Wildflower Bouquet: Pick all 15 wildflowers.Launch Into Orbit: Launch 10 Enemigos into the stratosphere by juggling them.Big Bang: Kill three Enemigos with one Barrel Rocket.Target Practice: Shoot nine tin cans with a BB Gun.Lepidopterist: Catch all 12 butterflies in the level.Zippy: Ride all the ziplines in the level.Exterminator: Destroy all the wasp nests.Cactus Decoy: Kill all the Cactus McCoy Impostors.Fly the Flag: Take down all the Alpaca Flags.Clean Up the Town: Kill all the Enemigos in the level.Tumbler: Destroy all the tumbleweeds in the level.Dirty Laundry: Take all eight sheets off the clotheslines.Cut to the Chase: Beat the level in 1:30.
Much like the original game, Cactus McCoy 2 involves traversing a series of levels, known as Areas, that are full of platforming challenges and Enemigos to fight. The next day, McCoy is awoken by his spirit guide, Popoca, who urges McCoy to go find Calavera and defeat Malana Mire to save Ella and protect the Serpent Blade. She and her goons knock McCoy out cold and kidnap Ella. She asks McCoy to help her and they agree to work together and split the treasure once they reach Calavera, but just then the notorious criminal Malana Mire ambushes the pair. As fate would have it, Ella is a descendant of the shaman and the last of her kind, so she's looking to find Calavera and claim her ancestors' riches. The war ended with Calavera crumbling down, and in the city's last moments the shaman sealed the Serpent Blade in a vault of treasures using an enchantment that could only be broken by one of the shaman's descendants. One day, a dark cult calling themselves the Reptaras invaded Calavera and tried to take the Serpent Blade to use its power for themselves, starting a war in the process. Ella explains that the map leads to the ruins of a sacred city called Calavera, which was once inhabited by a civilization known as the Volados and ruled by a winged shaman who used a magical item called the Serpent Blade to keep the city in balance. The woman then introduces herself as Ella Windstorm and explains that what she was really looking for was a map hidden inside the bird statue. McCoy almost dies but the mysterious newcomer saves him, revealing that she has wings in the process.
While fighting, the two accidentally trigger a booby trap and have to flee for their lives. As he goes to grab it, another treasure hunter appears and tries to take it from him.